Quantitative Imaging Methods Lab
Departments of Radiology and Medical Physics

Publications

    2025

  1. Tamada D, Navaratna R, Weaver JM, Hernando D and Reeder SB. Whole liver phase-based R2 mapping in liver iron overload within a breath-hold.. Magnetic resonance in medicine. 2025 February DOI PMID
  2. Denecken E, Arrieta C, Hernando D, Sotelo J, Mella H and Uribe S. Simultaneous acquisition of water, fat and velocity images using a phase-contrast 3p-Dixon method.. Magnetic resonance imaging. 2025 January;118:110341. DOI PMID

    3. 2024

  3. Allen TJ, van der Heijden RA, Simchick G and Hernando D. Reproducibility of liver ADC measurements using first moment optimized diffusion imaging.. Magnetic resonance in medicine. 2024 November DOI PMID
  4. Ma M, Cheng J, Li X, Fan Z, Wang C, Reeder SB and Hernando D. Prediction of MRI R_2^*relaxometry in the presence of hepatic steatosis by Monte Carlo simulations.. NMR in biomedicine. 2024 October:e5274. DOI PMID
  5. Buelo CJ, Velikina J, Mao L, Zhao R, Yuan Q, Ghasabeh MA, Ruschke S, Karampinos DC, Harris DT, Mattison RJ, Jeng MR, Pedrosa I, Kamel IR, Vasanawala S, Yokoo T, Reeder SB and Hernando D. Multicenter, multivendor validation of liver quantitative susceptibility mapping in patients with iron overload at 1.5 T and 3 T.. Magnetic resonance in medicine. 2024 September DOI PMID
  6. Simchick G, Allen TJ and Hernando D. Reproducibility of intravoxel incoherent motion quantification in the liver across field strengths and gradient hardware.. Magnetic resonance in medicine. 2024 August DOI PMID
  7. Keenan KE, Jordanova KV, Ogier SE, Tamada D, Bruhwiler N, Starekova J, Riek J, McCracken PJ and Hernando D. Phantoms for Quantitative Body MRI: a review and discussion of the phantom value.. Magma (New York, N.Y.). 2024 June DOI PMID
  8. Muslu Y, Tamada D, Roberts NT, Cashen TA, Mandava S, Kecskemeti SR, Hernando D and Reeder SB. Free-breathing, fat-corrected T (1)mapping of the liver with stack-of-stars MRI, and joint estimation of T (1), PDFF, R_2^*, and B_1^+.. Magnetic resonance in medicine. 2024 June DOI PMID
  9. Li X, Wang C, Huang J, Reeder SB and Hernando D. Effect of particle size on liver MRI R_2^*relaxometry: Monte Carlo simulation and phantom studies.. Magnetic resonance in medicine. 2024 May DOI PMID
  10. Simchick G, Zhao R, Yuan Q, Ghasabeh MA, Ruschke S, Karampinos DC, Harris DT, do Vale Souza R, Mattison RJ, Jeng MR, Pedrosa I, Kamel IR, Vasanawala S, Yokoo T, Reeder SB and Hernando D. Practical Application of Multivendor MRI-Based R2* Mapping for Liver Iron Quantification at 1.5 T and 3.0 T.. Journal of magnetic resonance imaging : JMRI. 2024 April DOI PMID
  11. Starekova J, Geng R, Wang Z, Zhang Y, Uboha NV, Pirasteh A and Hernando D. Precision of liver and pancreas apparent diffusion coefficients using motion-compensated gradient waveforms in DWI.. Magnetic resonance imaging. 2024 April DOI PMID
  12. Hu HH, Chen HS-M and Hernando D. Linearity and bias of proton density fat fraction across the full dynamic range of 0-100%: a multiplatform, multivendor phantom study using 1.5T and 3T MRI at two sites.. Magma (New York, N.Y.). 2024 February DOI PMID
  13. Tamada D, van der Heijden RA, Weaver J, Hernando D and Reeder SB. Confidence maps for reliable estimation of proton density fat fraction and R2* in the liver.. Magnetic resonance in medicine. 2024 January DOI PMID

    14. 2023

  14. Daudé P, Roussel T, Troalen T, Viout P, Hernando D, Guye M, Kober F, Confort Gouny S, Bernard M and Rapacchi S. Comparative review of algorithms and methods for chemical-shift-encoded quantitative fat-water imaging.. Magnetic resonance in medicine. 2023 October DOI PMID
  15. Liu D, Kadri A, Hernando D, Binkley N and Anderson PA. MRI-based vertebral bone quality score: relationship with age and reproducibility.. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2023 August DOI PMID
  16. Velikina JV, Zhao R, Buelo CJ, Samsonov AA, Reeder SB and Hernando D. Data adaptive regularization with reference tissue constraints for liver quantitative susceptibility mapping.. Magnetic resonance in medicine. 2023 March DOI PMID
  17. Wang J, Li X, Ma M, Wang C, Sirlin CB, Reeder SB and Hernando D. Monte Carlo modeling of hepatic steatosis based on stereology and spatial distribution of fat droplets.. Computer methods and programs in biomedicine. 2023 March;233:107494. DOI PMID
  18. Reeder SB, Yokoo T, França M, Hernando D, Alberich-Bayarri Á, Alústiza JM, Gandon Y, Henninger B, Hillenbrand C, Jhaveri K, Karçaaltıncaba M, Kühn J-P, Mojtahed A, Serai SD, Ward R, Wood JC, Yamamura J and Martí-Bonmatí L. Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.. Radiology. 2023 February:221856. DOI PMID
  19. Roberts NT, Tamada D, Muslu Y, Hernando D and Reeder SB. Confounder-corrected T1 mapping in the liver through simultaneous estimation of T1 , PDFF, R2* , and B1 in a single breath-hold acquisition. Magnetic resonance in medicine. 2023 January DOI PMID

    20. 2022

  20. Geng R, Buelo CJ, Sundaresan M, Starekova J, Panagiotopoulos N, Oechtering TH, Lawrence EM, Ignaciuk M, Reeder SB and Hernando D. Automated MR Image Prescription of the Liver Using Deep Learning: Development, Evaluation, and Prospective Implementation.. Journal of magnetic resonance imaging : JMRI. 2022 December DOI PMID
  21. Geng R, Zhang Y, Rice J, Muehler MR, Starekova J, Rutkowski DR, Uboha NV, Pirasteh A, Roldán-Alzate A, Guidon A and Hernando D. Motion-robust, blood-suppressed, reduced-distortion diffusion MRI of the liver.. Magnetic resonance in medicine. 2022 November DOI PMID
  22. Zhao R, Velikina J, Reeder SB, Vasanawala S, Jeng M and Hernando D. Validation of liver quantitative susceptibility mapping across imaging parameters at 1.5 T and 3.0 T using SQUID susceptometry as reference.. Magnetic resonance in medicine. 2022 November DOI PMID
  23. Cokic I, Chan SF, Guan X, Nair AR, Yang H-J, Liu T, Chen Y, Hernando D, Sykes J, Tang R, Butler J, Dohnalkova A, Kovarik L, Finney R, Kali A, Sharif B, Bouchard LS, Gupta R, Krishnam MS, Vora K, Tamarappoo B, Howarth AG, Kumar A, Francis J, Reeder SB, Wood JC, Prato FS and Dharmakumar R. Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium.. Nature communications. 2022 October;13:6394. DOI PMID
  24. Hernando D, Zhao R, Yuan Q, Aliyari Ghasabeh M, Ruschke S, Miao X, Karampinos DC, Mao L, Harris DT, Mattison RJ, Jeng MR, Pedrosa I, Kamel IR, Vasanawala S, Yokoo T and Reeder SB. Multicenter Reproducibility of Liver Iron Quantification with 1.5-T and 3.0-T MRI. Radiology. 2022 October:213256. DOI PMID
  25. Lawrence EM, Zhang Y, Starekova J, Wang Z, Pirasteh A, Wells SA and Hernando D. Reduced field-of-view and multi-shot DWI acquisition techniques: Prospective evaluation of image quality and distortion reduction in prostate cancer imaging. Magnetic resonance imaging. 2022 August;93:108-114. DOI PMID
  26. Simchick G and Hernando D. Precision of region of interest-based tri-exponential intravoxel incoherent motion quantification and the role of the Intervoxel spatial distribution of flow velocities. Magnetic resonance in medicine. 2022 August DOI PMID
  27. Starekova J, Zhao R, Colgan TJ, Johnson KM, Rehm JL, Wells SA, Reeder SB and Hernando D. Improved free-breathing liver fat and iron quantification using a 2D chemical shift-encoded MRI with flip angle modulation and motion-corrected averaging.. European radiology. 2022 March DOI PMID
  28. Roberts NT, Hernando D, Panagiotopoulos N and Reeder SB. Addressing concomitant gradient phase errors in time-interleaved chemical shift-encoded MRI fat fraction and R2* mapping with a pass-specific phase fitting method.. Magnetic resonance in medicine. 2022 February DOI PMID
  29. Simchick G, Geng R, Zhang Y and Hernando D. b value and first-order motion moment optimized data acquisition for repeatable quantitative intravoxel incoherent motion DWI.. Magnetic resonance in medicine. 2022 January DOI PMID

    30. 2021

  30. Henze Bancroft LC, Strigel RM, Macdonald EB, Longhurst C, Johnson J, Hernando D and Reeder SB. Proton density water fraction as a reproducible MR-based measurement of breast density. Magnetic resonance in medicine. 2021 November DOI PMID
  31. Kadri A, Binkley N, Hernando D and Anderson PA. Opportunistic Use of Lumbar Magnetic Resonance Imaging for Osteoporosis Screening. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2021 November DOI PMID
  32. Weingärtner S, Desmond KL, Obuchowski NA, Baessler B, Zhang Y, Biondetti E, Ma D, Golay X, Boss MA, Gunter JL, Keenan KE, Hernando D and Group IQMS. Development, validation, qualification, and dissemination of quantitative MR methods: Overview and recommendations by the ISMRM quantitative MR study group. Magnetic resonance in medicine. 2021 November DOI PMID
  33. Hernando D, Zhang Y and Pirasteh A. Quantitative diffusion MRI of the abdomen and pelvis. Medical physics. 2021 September DOI PMID
  34. Simchick G, Zhao R, Hamilton G, Reeder SB and Hernando D. Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T. Magnetic resonance in medicine. 2021 September DOI PMID
  35. Tannenbaum AP, Grimes MD, Brace CL, Johnson CJ, Koebe SD, Anzia LE, Mao L, Ricke WA, Hernando D, Roldan-Alzate A and Wells SA. Effect of Metabolic Syndrome on Anatomy and Function of the Lower Urinary Tract Assessed on MRI.. Urology. 2021 September DOI PMID
  36. Wang C, Reeder SB and Hernando D. Relaxivity-iron calibration in hepatic iron overload: Reproducibility and extension of a Monte Carlo model.. NMR in biomedicine. 2021 August:e4604. DOI PMID
  37. Navaratna R, Zhao R, Colgan TJ, Hu HH, Bydder M, Yokoo T, Bashir MR, Middleton MS, Serai SD, Malyarenko D, Chenevert T, Smith M, Henderson W, Hamilton G, Shu Y, Sirlin CB, Tkach JA, Trout AT, Brittain JH, Hernando D, Reeder SB and Committee RQIBAPDFFB. Temperature-corrected proton density fat fraction estimation using chemical shift-encoded MRI in phantoms.. Magnetic resonance in medicine. 2021 July;86:69-81. DOI PMID
  38. Geng R, Zhang Y, Starekova J, Rutkowski DR, Estkowski L, Roldán-Alzate A and Hernando D. Characterization and correction of cardiovascular motion artifacts in diffusion-weighted imaging of the pancreas.. Magnetic resonance in medicine. 2021 June DOI PMID
  39. Zhao R, Hernando D, Harris DT, Hinshaw LA, Li K, Ananthakrishnan L, Bashir MR, Duan X, Ghasabeh MA, Kamel IR, Lowry C, Mahesh M, Marin D, Miller J, Pickhardt PJ, Shaffer J, Yokoo T, Brittain JH and Reeder SB. Multisite multivendor validation of a quantitative MRI and CT compatible fat phantom.. Medical physics. 2021 June DOI PMID
  40. Muehler MR, Vigen K, Hernando D, Zhu A, Colgan TJ and Reeder SB. Reproducibility of liver R2* quantification for liver iron quantification from cardiac R2* acquisitions.. Abdominal radiology (New York). 2021 May DOI PMID
  41. Colgan TJ, Zhao R, Roberts NT, Hernando D and Reeder SB. Limits of Fat Quantification in the Presence of Iron Overload.. Journal of magnetic resonance imaging : JMRI. 2021 March DOI PMID
  42. Hu HH, Yokoo T, Bashir MR, Sirlin CB, Hernando D, Malyarenko D, Chenevert TL, Smith MA, Serai SD, Middleton MS, Henderson WC, Hamilton G, Shaffer J, Shu Y, Tkach JA, Trout AT, Obuchowski N, Brittain JH, Jackson EF, Reeder SB and Committee RQIBAPB. Linearity and Bias of Proton Density Fat Fraction as a Quantitative Imaging Biomarker: A Multicenter, Multiplatform, Multivendor Phantom Study.. Radiology. 2021 March;298:640-651. DOI PMID
  43. Kasza I, Kühn J-P, Völzke H, Hernando D, Xu YG, Siebert JW, Gibson AL, Yen C-LE, Nelson DW, MacDougald OA, Richardson NE, Lamming DW, Kern PA and Alexander CM. Contrasting recruitment of skin-associated adipose depots during cold challenge of mouse and human. The Journal of physiology. 2021 March DOI PMID
  44. Rajlawot K, Jiang T, Zhou J, Lin C, Kuang S, Chen J, Zhang Y, Yang H, Deng Y, He B, Hernando D, Reeder SB and Wang J. Accuracies of Chemical Shift In/Opposed Phase and Chemical Shift Encoded Magnetic Resonance Imaging to Detect Intratumoral Fat in Hepatocellular Carcinoma. Journal of magnetic resonance imaging : JMRI. 2021 February DOI PMID
  45. Kee Y, Sandino CM, Syed AB, Cheng JY, Shimakawa A, Colgan TJ, Hernando D and Vasanawala SS. Free-breathing , mapping of hepatic iron overload in children using 3D multi-echo UTE cones MRI. Magnetic resonance in medicine. 2021 January DOI PMID

    46. 2020

  46. Lawrence EM, Roberts NT, Hernando D, Mao L and Reeder SB. Effect of noise and estimator type on bias for analysis of liver proton density fat fraction. Magnetic resonance imaging. 2020 October;74:244-249. DOI PMID
  47. Roberts NT, Hinshaw LA, Colgan TJ, Ii T, Hernando D and Reeder SB. B0 and B 1 inhomogeneities in the liver at 1.5 T and 3.0 T. Magnetic resonance in medicine. 2020 October DOI PMID
  48. Hernando D, Cook RJ, Qazi N, Longhurst CA, Diamond CA and Reeder SB. Complex confounder-corrected R2* mapping for liver iron quantification with MRI. European radiology. 2020 August DOI PMID
  49. Luo H, Zhu A, Wiens CN, Starekova J, Shimakawa A, Reeder SB, Johnson KM and Hernando D. Free-breathing liver fat and , quantification using motion-corrected averaging based on a nonlocal means algorithm. Magnetic resonance in medicine. 2020 August DOI PMID
  50. Zhao R, Hamilton G, Brittain JH, Reeder SB and Hernando D. Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver. Magnetic resonance in medicine. 2020 August DOI PMID
  51. Zhao R, Zhang Y, Wang X, Colgan TJ, Rehm JL, Reeder SB, Johnson KM and Hernando D. Motion-robust, high-SNR liver fat quantification using a 2D sequential acquisition with a variable flip angle approach. Magnetic resonance in medicine. 2020 April DOI PMID
  52. Zhang Y, Wells SA, Triche BL, Kelcz F and Hernando D. Stimulated-echo diffusion-weighted imaging with moderate b values for the detection of prostate cancer. European radiology. 2020 February DOI PMID
  53. Wells SA, Schubert T, Motosugi U, Sharma SD, Campo CA, Kinner S, Woo KM, Hernando D and Reeder SB. Pharmacokinetics of Ferumoxytol in the Abdomen and Pelvis: A Dosing Study with 1.5- and 3.0-T MRI Relaxometry. Radiology. 2020 January;294:108-116. DOI PMID
  54. Pewowaruk R, Rutkowski D, Hernando D, Kumapayi BB, Bushman W and Roldán-Alzate A. A pilot study of bladder voiding with real-time MRI and computational fluid dynamics.. PloS one. 2020;15:e0238404. DOI PMID

    55. 2019

  55. Wang X, Hernando D and Reeder SB. Phase-based T2 mapping with gradient echo imaging. Magnetic resonance in medicine. 2019 December DOI PMID
  56. Hu HH, Branca RT, Hernando D, Karampinos DC, Machann J, McKenzie CA, Wu HH, Yokoo T and Velan SS. Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop. Magnetic resonance in medicine. 2019 November DOI PMID
  57. Wang X, Colgan TJ, Hinshaw LA, Roberts NT, Bancroft LCH, Hamilton G, Hernando D and Reeder SB. T1-corrected quantitative chemical shift-encoded MRI. Magnetic resonance in medicine. 2019 November DOI PMID
  58. Peña-Nogales Ó, Hernando D, Aja-Fernández S and de Luis-Garcia R. Determination of optimized set of b-values for Apparent Diffusion Coefficient mapping in liver Diffusion-Weighted MRI. Journal of magnetic resonance. 2019 October;310:106634. DOI PMID
  59. Zhu A, Reeder SB, Johnson KM, Nguyen SM, Fain SB, Bird IM, Golos TG, Wieben O, Shah DM and Hernando D. Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.. Magnetic resonance imaging. 2019 October;65:100-108. DOI PMID
  60. Colgan TJ, Knobloch G, Reeder SB and Hernando D. Sensitivity of quantitative relaxometry and susceptibility mapping to microscopic iron distribution. Magnetic resonance in medicine. 2019 August DOI PMID
  61. Kasza I, Adler D, Nelson DW, Eric Yen C-L, Dumas S, Ntambi JM, MacDougald OA, Hernando D, Porter WP, Best FA and Alexander CM. Evaporative cooling provides a major metabolic energy sink. Molecular metabolism. 2019 July DOI PMID
  62. Zhu A, Hernando D, Johnson KM and Reeder SB. Characterizing a short T2* signal component in the liver using ultrashort TE chemical shift-encoded MRI at 1.5T and 3.0T. Magnetic resonance in medicine. 2019 July DOI PMID
  63. Zhu A, Reeder SB, Johnson KM, Nguyen SM, Golos TG, Shimakawa A, Muehler MR, Francois CJ, Bird IM, Fain SB, Shah DM, Wieben O and Hernando D. Evaluation of a motion-robust 2D chemical shift-encoded technique for R2* and field map quantification in ferumoxytol-enhanced MRI of the placenta in pregnant rhesus macaques. Journal of magnetic resonance imaging : JMRI. 2019 July DOI PMID
  64. Liu TT, Thomas S, Mclean DT, Roldan-Alzate A, Hernando D, Ricke EA and Ricke WA. Prostate enlargement and altered urinary function are part of the aging process. Aging. 2019 May;11:2653-2669. DOI PMID
  65. Pooler BD, Hernando D and Reeder SB. Clinical Implementation of a Focused MRI Protocol for Hepatic Fat and Iron Quantification. AJR. American journal of roentgenology. 2019 March:1-6. DOI PMID
  66. Zhang Y, Peña-Nogales Ó, Holmes JH and Hernando D. Motion-robust and blood-suppressed M1-optimized diffusion MR imaging of the liver. Magnetic resonance in medicine. 2019 March DOI PMID
  67. Rabanillo-Viloria I, Zhu A, Aja-Fernández S, Alberola-López C and Hernando D. Computation of exact g-factor maps in 3D GRAPPA reconstructions. Magnetic resonance in medicine. 2019 February;81:1353-1367. DOI PMID
  68. Park CC, Hooker C, Hooker JC, Bass E, Haufe W, Schlein A, Covarrubias Y, Heba E, Bydder M, Wolfson T, Gamst A, Loomba R, Schwimmer J, Hernando D, Reeder SB, Middleton M, Sirlin CB and Hamilton G. Assessment of a high-SNR chemical-shift-encoded MRI with complex reconstruction for proton density fat fraction (PDFF) estimation overall and in the low-fat range. Journal of magnetic resonance imaging : JMRI. 2019 January;49:229-238. DOI PMID
  69. Zhang Y, Wells SA and Hernando D. Stimulated echo based mapping (STEM) of T1, T2, and apparent diffusion coefficient: Validation and protocol optimization. Magnetic Resonance in Medicine. 2019 January;81(1):167-181. DOI PMID
  70. Yi SY, Barnett BR, Torres-Velázquez M, Zhang Y, Hurley SA, Rowley PA, Hernando D and Yu J-PJ. Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI. Frontiers in neuroscience. 2019;13:81. DOI PMID

    71. 2018

  71. Pooler BD, Hernando D, Ruby JA, Ishii H, Shimakawa A and Reeder SB. Validation of a motion-robust 2D sequential technique for quantification of hepatic proton density fat fraction during free breathing. Journal of magnetic resonance imaging : JMRI. 2018 December;48:1578-1585. DOI PMID
  72. Peña-Nogales Ó, Zhang Y, Wang X, de Luis-Garcia R, Aja-Fernández S, Holmes JH and Hernando D. Optimized Diffusion-Weighting Gradient Waveform Design (ODGD) formulation for motion compensation and concomitant gradient nulling. Magnetic Resonance in Medicine. 2018 November;81(2):989-1003. DOI PMID
  73. van Heeswijk RB, Colotti R, Darçot E, Delacoste J, Pellegrin M, Piccini D and Hernando D. Chemical shift encoding (CSE) for sensitive fluorine-19 MRI of perfluorocarbons with complex spectra. Magnetic Resonance in Medicine. 2018 September;79(5):2724-2730. DOI PMID
  74. Pickhardt PJ, Graffy PM, Reeder SB, Hernando D and Li K. Quantification of liver fat content with unenhanced MDCT: Phantom and clinical correlation with MRI proton density fat fraction. American Journal of Roentgenology. 2018 September;211(3):W151-W157. DOI PMID
  75. Zhang Y, Holmes J, Rabanillo I, Guidon A, Wells S and Hernando D. Quantitative diffusion MRI using reduced field-of-view and multi-shot acquisition techniques: Validation in phantoms and prostate imaging. Magnetic Resonance Imaging. 2018 September;51:173-181. DOI PMID
  76. Ludwig KD, Hernando D, Roberts NT, van Heeswijk RB and Fain SB. A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI. Magnetic Resonance in Medicine. 2018 August;79(4):2183-2189. DOI PMID
  77. Jeong D, Raghunand N, Hernando D, Poch M, Jeong K, Eck B and Dhillon J. Quantification of sarcomatoid differentiation in renal cell carcinoma on magnetic resonance imaging. Quantitative Imaging in Medicine and Surgery. 2018 May;8(4):373-382. DOI PMID
  78. Knobloch G, Colgan T, Wiens CN, Wang X, Schubert T, Hernando D, Sharma SD and Reeder SB. Relaxivity of Ferumoxytol at 1.5 T and 3.0 T. Investigative Radiology. 2018 May;53(5):257-263. DOI PMID
  79. Pirasteh A, Yuan Q, Hernando D, Reeder SB, Pedrosa I and Yokoo T. Inter-method reproducibility of biexponential R2 MR relaxometry for estimation of liver iron concentration. Magnetic Resonance in Medicine. 2018 May DOI PMID
  80. Ichikawa S, Motosugi U, Hernando D, Morisaka H, Enomoto N, Matsuda M and Onishi H. Histological grading of hepatocellular carcinomas with intravoxel incoherent motion diffusion-weighted imaging: Inconsistent results depending on the fitting method. Magnetic Resonance in Medical Sciences. 2018 April;17(2):168-173. DOI PMID
  81. Rabanillo I, Aja-Fernandez S, Alberola-Lopez C and Hernando D. Exact Calculation of Noise Maps and g-Factor in GRAPPA Using a k-Space Analysis. IEEE Transactions on Medical Imaging. 2018 February;37(2):480-490. DOI PMID
  82. Yokoo T, Serai SD, Pirasteh A, Bashir MR, Hamilton G, Hernando D, Hu HH, Hetterich H, Kühn J-P, Kukuk GM, Loomba R, Middleton MS, Obuchowski NA, Song JS, Tang A, Wu X, Reeder SB and Sirlin CB. Linearity, bias, and precision of hepatic proton density fat fraction measurements by using MR imaging: A meta-analysis. Radiology. 2018 February;286(2):486-498. DOI PMID
  83. Roberts NT, Hernando D, Holmes JH, Wiens CN and Reeder SB. Noise properties of proton density fat fraction estimated using chemical shift–encoded MRI. Magnetic Resonance in Medicine. 2018 January;80(2):685-695. DOI PMID

    84. 2017

  84. Motosugi U, Hernando D, Wiens C, Bannas P and Reeder SB. High SNR acquisitions improve the repeatability of liver fat quantification using confounder-corrected chemical shift-encoded MR imaging. Magnetic Resonance in Medical Sciences. 2017 October;16(4):332-339. DOI PMID
  85. Campo CA, Hernando D, Schubert T, Bookwalter CA, Van Pay AJ and Reeder SB. Standardized approach for ROI-based measurements of proton density fat fraction and r2 in the liver. American Journal of Roentgenology. 2017 September;209(3):592-603. DOI PMID
  86. Colgan TJ, Hernando D, Sharma SD and Reeder SB. The effects of concomitant gradients on chemical shift encoded MRI. Magnetic Resonance in Medicine. 2017 September;78(2):730-738. DOI PMID
  87. Kühn J-P, Meffert P, Heske C, Kromrey M-L, Schmidt CO, Mensel B, Völzke H, Lerch MM, Hernando D, Mayerle J and Reeder SB. Prevalence of fatty liver disease and hepatic iron overload in a northeastern German population by using quantitative MR imaging. Radiology. 2017 September;284(3):706-716. DOI PMID
  88. Sharma SD, Fischer R, Schoennagel BP, Nielsen P, Kooijman H, Yamamura J, Adam G, Bannas P, Hernando D and Reeder SB. MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload: Comparison with SQUID-based biomagnetic liver susceptometry. Magnetic Resonance in Medicine. 2017 August;78(1):264-270. DOI PMID
  89. Horng DE, Hernando D and Reeder SB. Quantification of liver fat in the presence of iron overload. Journal of Magnetic Resonance Imaging. 2017 July;45(2):428-439. DOI PMID
  90. Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, Pan L, Shaffer JM, Sofue K, Szeverenyi NM, Welch EB, Yuan Q, Bashir MR, Kamel IR, Rice MJ, Sirlin CB, Yokoo T and Reeder SB. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat–water phantom. Magnetic Resonance in Medicine. 2017 April;77(4):1516-1524. DOI PMID
  91. Wang X, Reeder SB and Hernando D. An acetone-based phantom for quantitative diffusion MRI. Journal of Magnetic Resonance Imaging. 2017 April;46(6):1683-1692. DOI PMID
  92. Artz NS, Wiens CN, Smith MR, Hernando D, Samsonov A and Reeder SB. Accelerating fully phase-encoded MRI near metal using multiband radiofrequency excitation. Magnetic Resonance in Medicine. 2017 March;77(3):1223-1230. DOI PMID
  93. Haufe WM, Wolfson T, Hooker CA, Hooker JC, Covarrubias Y, Schlein AN, Hamilton G, Middleton MS, Angeles JE, Hernando D, Reeder SB, Schwimmer JB and Sirlin CB. Accuracy of PDFF estimation by magnitude-based and complex-based MRI in children with MR spectroscopy as a reference. Journal of Magnetic Resonance Imaging. 2017 March;46(6):1641-1647. DOI PMID
  94. Kramer H, Pickhardt PJ, Kliewer MA, Hernando D, Chen G-H, Zagzebski JA and Reeder SB. Accuracy of liver fat quantification with advanced CT, MRI, and ultrasound techniques: Prospective comparison with MR spectroscopy. American Journal of Roentgenology. 2017 January;208(1):92-100. DOI PMID

    95. 2016

  95. Henze Bancroft LC, Strigel RM, Hernando D, Johnson KM, Kelcz F, Kijowski R and Block WF. Utilization of a balanced steady state free precession signal model for improved fat/water decomposition. Magnetic Resonance in Medicine. 2016 May;75(3):1269-1277. DOI PMID
  96. Mahlke C, Hernando D, Jahn C, Cigliano A, Ittermann T, Mössler A, Kromrey M-L, Domaska G, Reeder SB and Kühn J-P. Quantification of liver proton-density fat fraction in 7.1T preclinical MR systems: Impact of the fitting technique. Journal of Magnetic Resonance Imaging. 2016 May;44(6):1425-1431. DOI PMID
  97. Reeder SB, Smith MR and Hernando D. Mathematical optimization of contrast concentration for t1-weighted spoiled gradient echo imaging. Magnetic Resonance in Medicine. 2016 May;75(4):1556-1564. DOI PMID
  98. Wang X, Hernando D and Reeder SB. Sensitivity of chemical shift-encoded fat quantification to calibration of fat MR spectrum. Magnetic Resonance in Medicine. 2016 April;75(2):845-851. DOI PMID
  99. Bannas P, Motosugi U, Hernando D, Rahimi MS, Holmes JH and Reeder SB. Combined gadoxetic acid and gadofosveset enhanced liver MRI: A feasibility and parameter optimization study. Magnetic Resonance in Medicine. 2016;75(1):318-328. DOI PMID
  100. Motosugi U, Bannas P, Hernando D, Rahimi MS, Holmes JH and Reeder SB. Intraindividual crossover comparison of gadoxetic acid dose for liver MRI in normal volunteers. Magnetic Resonance in Medical Sciences. 2016;15(1):60-72. DOI PMID

    101. 2015

  101. Alexander CM, Kasza I, Yen C-LE, Reeder SB, Hernando D, Gallo RL, Jahoda CAB, Horsley V and MacDougald OA. Dermal white adipose tissue: A new component of the thermogenic response. Journal of Lipid Research. 2015;56(11):2061-2069. DOI PMID
  102. Attenberger UI, Morelli J, Budjan J, Henzler T, Sourbron S, Bock M, Riffel P, Hernando D, Ong MM and Schoenberg SO. Fifty years of technological innovation: Potential and limitations of current technologies in abdominal magnetic resonance imaging and computed tomography. Investigative Radiology. 2015;50(9):584-593. DOI PMID
  103. Baiu DC, Artz NS, McElreath MR, Menapace BD, Hernando D, Reeder SB, Grüttner C and Otto M. High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles. Nanomedicine. 2015;10(19):2973-2988. DOI PMID
  104. Bannas P, Kramer H, Hernando D, Agni R, Cunningham AM, Mandal R, Motosugi U, Sharma SD, Munoz del Rio A, Fernandez L and Reeder SB. Quantitative magnetic resonance imaging of hepatic steatosis: Validation in ex vivo human livers. Hepatology. 2015;62(5):1444-1455. DOI PMID
  105. Hernando D, Wells SA, Vigen KK and Reeder SB. Effect of hepatocyte-specific gadolinium-based contrast agents on hepatic fat-fraction and R2. Magnetic Resonance Imaging. 2015;33(1):43-50. DOI PMID
  106. Hu HH and Hernando D. Direct water-fat imaging methods: Chemical shift-selective and chemical shift-encoded MRI. eMagRes. 2015;4(3):673-687. DOI
  107. Motosugi U, Hernando D, Bannas P, Holmes JH, Wang K, Shimakawa A, Iwadate Y, Taviani V, Rehm JL and Reeder SB. Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI. Journal of Magnetic Resonance Imaging. 2015;42(5):1241-1248. DOI PMID
  108. Rehm JL, Wolfgram PM, Hernando D, Eickhoff JC, Allen DB and Reeder SB. Proton density fat-fraction is an accurate biomarker of hepatic steatosis in adolescent girls and young women. European Radiology. 2015;25(10):2921-2930. DOI PMID
  109. Sharma SD, Artz NS, Hernando D, Horng DE and Reeder SB. Improving chemical shift encoded water-fat separation using object-based information of the magnetic field inhomogeneity. Magnetic Resonance in Medicine. 2015;73(2):597-604. DOI PMID
  110. Sharma SD, Hernando D, Horng DE and Reeder SB. Quantitative susceptibility mapping in the abdomen as an imaging biomarker of hepatic iron overload. Magnetic Resonance in Medicine. 2015;74(3):673-683. DOI PMID
  111. Smith MR, Artz NS, Wiens C, Hernando D and Reeder SB. Characterizing the limits of MRI near metallic prostheses. Magnetic Resonance in Medicine. 2015;74(6):1564-1573. DOI PMID

    112. 2014

  112. Bannas P, Hernando D, Motosugi U, Roldan A and Reeder SB. Emerging quantitative MRI biomarkers of diffuse liver disease. Clinical Liver Disease. 2014 December;4(6):129-132. DOI
  113. Bannas P, Motosugi U, Ichikawa S, Hernando D and Reeder SB. Primer on magnetic resonance imaging of the liver. Clinical Liver Disease. 2014 November;4(5):120-123. DOI
  114. Artz NS, Hernando D, Taviani V, Samsonov A, Brittain JH and Reeder SB. Spectrally resolved fully phase-encoded three-dimensional fast spin-echo imaging. Magnetic Resonance in Medicine. 2014;71(2):681-690. DOI PMID
  115. Hernando D, Levin YS, Sirlin CB and Reeder SB. Quantification of liver iron with MRI: State of the art and remaining challenges. Journal of Magnetic Resonance Imaging. 2014;40(5):1003-1021. DOI PMID
  116. Hernando D, Sharma SD, Kramer H and Reeder SB. On the confounding effect of temperature on chemical shift-encoded fat quantification. Magnetic Resonance in Medicine. 2014;72(2):464-470. DOI PMID
  117. Kühn J-P, Hernando D, Mensel B, Krüger PC, Ittermann T, Mayerle J, Hosten N and Reeder SB. Quantitative chemical shift-encoded MRI is an accurate method to quantify hepatic steatosis. Journal of Magnetic Resonance Imaging. 2014;39(6):1494-1501. DOI PMID
  118. Kühn J-P, Holmes JH, Brau ACS, Iwadate Y, Hernando D and Reeder SB. Navigator flip angle optimization for free-breathing T1-weighted hepatobiliary phase imaging with gadoxetic acid. Journal of Magnetic Resonance Imaging. 2014;40(5):1129-1136. DOI PMID
  119. Kühn J-P, Jahn C, Hernando D, Siegmund W, Hadlich S, Mayerle J, Pfannmöller J, Langner S and Reeder S. T1 bias in chemical shift-encoded liver fat-fraction: Role of the flip angle. Journal of Magnetic Resonance Imaging. 2014;40(4):875-883. DOI PMID
  120. Taviani V, Hernando D, Francois CJ, Shimakawa A, Vigen KK, Nagle SK, Schiebler ML, Grist TM and Reeder SB. Whole-heart chemical shift encoded water-fat MRI. Magnetic resonance in medicine. 2014;72(3):718-725. DOI PMID

    121. 2013

  121. Aja-Ferńandez S, Luis-Garćía RD, Alberola-Ĺopez C and Hernando D. Quantitative diffusion MRI in the presence of noise: Effects of filtering and fitting technique. Optics InfoBase Conference Papers. 2013
  122. Bülow R, Mensel B, Meffert P, Hernando D, Evert M and Kühn J-P. Diffusion-weighted magnetic resonance imaging for staging liver fibrosis is less reliable in the presence of fat and iron. European Radiology. 2013;23(5):1281-1287. DOI PMID
  123. Haldar JP, Hernando D and Liang Z-P. Erratum: Compressed-sensing MRI with random encoding (IEEE Transactions on Medical Imaging). IEEE Transactions on Medical Imaging. 2013;32(7):1362. DOI
  124. Hansmann J, Hernando D and Reeder SB. Fat confounds the observed apparent diffusion coefficient in patients with hepatic steatosis. Magnetic Resonance in Medicine. 2013;69(2):545-552. DOI PMID
  125. Hernando D, Cook RJ, Diamond C and Reeder SB. Magnetic susceptibility as a B0 field strength independent MRI biomarker of liver iron overload. Magnetic Resonance in Medicine. 2013;70(3):648-656. DOI PMID
  126. Hernando D, Kramer JH and Reeder SB. Multipeak fat-corrected complex R2* relaxometry: Theory, optimization, and clinical validation. Magnetic Resonance in Medicine. 2013;70(5):1319-1331. DOI PMID
  127. Hernando D, Kühn J-P, Mensel B, Völzke H, Puls R, Hosten N and Reeder SB. R2* estimation using “in-phase” echoes in the presence of fat: The effects of complex spectrum of fat. Journal of Magnetic Resonance Imaging. 2013;37(3):717-726. DOI PMID
  128. Horng DE, Hernando D, Hines CDG and Reeder SB. Comparison of R2* correction methods for accurate fat quantification in fatty liver. Journal of Magnetic Resonance Imaging. 2013;37(2):414-422. DOI PMID
  129. Kühn J-P, Hernando D, Meffert PJ, Reeder S, Hosten N, Laqua R, Steveling A, Ender S, Schröder H and Pillich D-T. Proton-density fat fraction and simultaneous R2*estimation as an MRI tool for assessment of osteoporosis. European Radiology. 2013;23(12):3432-3439. DOI PMID
  130. Poonawalla AH, Sjoberg BP, Rehm JL, Hernando D, Hines CD, Irarrazaval P and Reeder SB. Adipose tissue MRI for quantitative measurement of central obesity. Journal of Magnetic Resonance Imaging. 2013;37(3):707-716. DOI PMID

    131. 2012

  131. Hernando D, Hines CDG, Yu H and Reeder SB. Addressing phase errors in fat-water imaging using a mixed magnitude/complex fitting method. Magnetic Resonance in Medicine. 2012;67(3):638-644. DOI PMID
  132. Hernando D, Vigen KK, Shimakawa A and Reeder SB. R2* mapping in the presence of macroscopic B0 field variations. Magnetic Resonance in Medicine. 2012;68(3):830-840. DOI PMID
  133. Hines CDG, Agni R, Roen C, Rowland I, Hernando D, Bultman E, Horng D, Yu H, Shimakawa A, Brittain JH and Reeder SB. Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse. Journal of Magnetic Resonance Imaging. 2012;35(4):844-851. DOI PMID
  134. Hu HH, Börnert P, Hernando D, Kellman P, Ma J, Reeder S and Sirlin C. ISMRM workshop on fat-water separation: Insights, applications and progress in MRI. Magnetic Resonance in Medicine. 2012;68(2):378-388. DOI PMID
  135. Kühn J-P, Hernando D, Muñoz Del Rio A, Evert M, Kannengiesser S, Völzke H, Mensel B, Puls R, Hosten N and Reeder SB. Effect of multipeak spectral modeling of fat for liver iron and fat quantification: Correlation of biopsy with MR imaging results. Radiology. 2012;265(1):133-142. DOI PMID
  136. Reeder SB, Bice EK, Yu H, Hernando D and Pineda AR. On the performance of T 2* correction methods for quantification of hepatic fat content. Magnetic Resonance in Medicine. 2012;67(2):389-404. DOI PMID
  137. Yin X, Guo Y, Li W, Huo E, Zhang Z, Nicolai J, Kleps RA, Hernando D, Katsaggelos AK, Omary RA and Larson AC. Chemical shift MR imaging methods for the quantification of transcatheter lipiodol delivery to the liver: Preclinical feasibility studies in a rodent model. Radiology. 2012;263(3):714-722. DOI PMID

    138. 2011

  138. Haldar JP, Hernando D and Liang Z-P. Compressed-sensing MRI with random encoding. IEEE Transactions on Medical Imaging. 2011;30(4):893-903. DOI PMID
  139. Hernando D, Karampinos DC, King KF, Haldar JP, Majumdar S, Georgiadis JG and Liang Z-P. Removal of olefinic fat chemical shift artifact in diffusion MRI. Magnetic Resonance in Medicine. 2011;65(3):692-701. DOI PMID
  140. Van AT, Hernando D and Sutton BP. Motion-induced phase error estimation and correction in 3D diffusion tensor imaging. IEEE Transactions on Medical Imaging. 2011;30(11):1933-1940. DOI PMID

    141. 2010

  141. Hernando D, Kellman P, Haldar JP and Liang Z-P. Robust water/fat separation in the presence of large field inhomogeneities using a graph cut algorithm. Magnetic Resonance in Medicine. 2010;63(1):79-90. DOI PMID
  142. Hernando D, Liang Z-P and Kellman P. Chemical shift-based water/fat separation: A comparison of signal models. Magnetic Resonance in Medicine. 2010;64(3):811-822. DOI PMID
  143. Kellman P, Hernando D and Arai AE. Myocardial Fat Imaging. Current Cardiovascular Imaging Reports. 2010;3(2):83-91. DOI
  144. Peng X, Nguyen H, Haldar J, Hernando D, Wang X-P and Liang Z-P. Correction of field inhomogeneity effects on limited k-space MRSI data using anatomical constraints. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC’10. 2010:883-886. DOI PMID

    145. 2009

  145. Haldar JP and Hernando D. Rank-constrained solutions to linear matrix equations using powerfactorization. IEEE Signal Processing Letters. 2009;16(7):584-587. DOI
  146. Haldar JP, Hernando D and Liang Z-P. Super-Resolution reconstruction of mr image sequences with contrast modeling. Proceedings – 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2009. 2009:266-269. DOI
  147. Keilman P, Hernando D, Shah S, Zuehlsdorff S, Jerecic R, Mancini C, Liang Z-P and Arai AE. Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium. Magnetic Resonance in Medicine. 2009;61(1):215-221. DOI PMID

    148. 2008

  148. Haldar JP, Hernando D, Song S-K and Liang Z-P. Anatomically constrained reconstruction from noisy data. Magnetic Resonance in Medicine. 2008;59(4):810-818. DOI PMID
  149. Hernando D, Haldar JP, Sutton BP, Ma J, Kellman P and Liang Z-P. Joint estimation of water/fat images and field inhomogeneity map. Magnetic Resonance in Medicine. 2008;59(3):571-580. DOI PMID
  150. Hernando D, Kellman P, Haldar JP and Liang Z-P. A network flow method for improved MR field map estimation in the presence of water and fat. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS’08 – “Personalized Healthcare through Technology”. 2008:82-85. PMID

    151. 2007

  151. Haldar JP, Hernando D, Budde MD, Wang Q, Song S-K and Liang Z-P. High-resolution MR metabolic imaging. Annual International Conference of the IEEE Engineering in Medicine and Biology – Proceedings. 2007:4324-4326. DOI PMID
  152. Haldar JP, Hernando D and Liang Z-P. Shaping spatial response functions for optimal estimation of compartmental signals from limited fourier data. 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro – Proceedings. 2007:1364-1367. DOI
  153. Hernando D, Haldar J, Sutton B and Liang Z-P. Removal of lipid signal in mrsi using spatial-spectral constraints. 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro – Proceedings. 2007:1360-1363. DOI

    154. 2006

  154. Haldar JP, Jacob M, Ebel A, Zhu X, Schuff N, Hernando D, Sutton BP and Liang Z-P. Regularized inversion of noisy, incomplete MR spectroscopic imaging data with anatomical prior. 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro – Proceedings. 2006;2006:718-721.
  155. Hernando D, Haldar J and Liang Z-P. Reduced-encoding MRI using higher-order generalized series. 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro – Proceedings. 2006;2006:29-32.

    156. 2005

  156. Hernando D, Crespi V and Cybenko G. Efficient computation of the Hidden Markov model entropy for a given observation sequence. IEEE Transactions on Information Theory. 2005;51(7):2681-2685. DOI

    157. 2004

  157. Hernando D and Crespi V. Sampling theory for process detection with applications to surveillance and tracking. Proceedings of SPIE – The International Society for Optical Engineering. 2004;5403(PART 1):143-152. DOI